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Complement in Immune-mediated Glomerulonephritis

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Dr Sidharth Sethi, Gurugram    11 January 2018

  1. C3G is minimally responsive to traditional immune suppression and randomized controlled trials to support therapy are lacking (Nester CM, et al. Curr Opin Nephrol Hypertens. 2013;22(2):231-7).
  2. Anticellular immune suppression and plasma therapy have limited efficacy in C3G (Nester CM, et al. Curr Opin Nephrol Hypertens. 2013;22(2):231-7).
  3. The use of terminal complement blockade and a few other reports suggest that the anticomplement drug eculizumab may offer a therapeutic advantage in C3G (Nester CM, et al. Curr Opin Nephrol Hypertens. 2013;22(2):231-7).
  4. It was seen in GLOSEN study that immunosuppressive treatments, particularly corticosteroids plus mycophenolate mofetil, can be beneficial in C3 glomerulonephritis. (Rabasco C, et al. Kidney Int. 2015;88(5):1153-60).

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